对25例严重癫痫患儿采取在血药浓度监测下单用大剂量卡马西平的治疗方法。结果9例患儿发作停止,10例发作减少50%以上。最终所服卡马西平的剂量为每天23～34mg/kg,平均26±6mg/kg,测定末次血药浓度为9.7～16.4mg/L,平均11.7±1.8mg/L。3例患儿出现轻微卡马西平毒副反应,调整剂量后很快消失。 Twenty-five children with severe epilepsy were treated with high-dose carbamazepine alone at the plasma concentration monitoring level. Results The onset of seizures in 9 patients was stopped, and 10 seizures were reduced by more than 50%. The final dose of carbamazepine taken daily 23 ~ 34mg / kg, an average of 26 ± 6mg / kg, the determination of the final plasma concentration of 9.7 ~ 16.4mg / L, an average of 11.7 ± 1.8mg / L. Three patients had mild carbamazepine side effects and disappeared soon after the dose was adjusted.