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目的:探究临床诊断巨细胞病毒感染患儿的过程中,检测尿巨细胞病毒DNA与血清巨细胞病毒抗体的临床意义,为临床儿科诊断奠定基础。方法:自我院2015年5月-2016年9月期间收治的120例巨细胞病毒感染患儿,对比患儿应用不同诊断方案进行治疗,观察诊断效果。结果:予以不同的检测方法后,两种单一检测方法诊断结果的阳性率及特异性均无显著的差异(P>0.05);但联合检测的诊断结果均显著高于两种单一检测结果,如阳性率、特异性结果,差异显著(P<0.05)。对比治疗前后所有患儿的两项指标变化情况,发现两组指标均明显下降,存在显著的差异(P<0.05)。结论:临床治疗巨细胞病毒感染患儿的过程中,联合检测尿巨细胞病毒DNA与血清巨细胞病毒抗体可予以准确的诊断,有利于后续的临床治疗,应广泛推广。
Objective: To explore the clinical significance of detection of cytomegalovirus DNA and cytomegalovirus antibody during the clinical diagnosis of children with cytomegalovirus infection, and to lay a foundation for clinical pediatric diagnosis. Methods: From May 2015 to September 2016 in our hospital, 120 children with CMV infection were enrolled. Children with different cytotoxicity were treated with different diagnostic schemes to observe the diagnostic results. Results: There was no significant difference in the positive rate and specificity between the two single detection methods after applying different detection methods (P> 0.05). However, the diagnostic results of the combined detection were significantly higher than those of the two single detection methods, such as Positive rate, specific results, the difference was significant (P <0.05). Comparing the changes of two indexes in all children before and after treatment, the indexes of both groups were significantly decreased, with significant difference (P <0.05). Conclusion: In the clinical treatment of children with cytomegalovirus infection, combined detection of cytomegalovirus DNA and serum cytomegalovirus antibodies can be accurately diagnosed, is conducive to follow-up clinical treatment, should be widely promoted.