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自1957年由Arnold 等合成环磷酰胺(下简称CP)以来,一直作为抗肿瘤药广泛应用于临床,本品具有肿瘤暂时性缩小、减少病人疼痛、改善食欲和增强体质的作用。近年来,CP对于一些非肿瘤性疾病如风湿性关节炎、周身性红斑狼疮的治疗也取得一定疗效。此外,CP尚可用作器官移植的免疫抑制剂。但是,由于CP 极易水解,且水解产物又无抗肿瘤活性,因而,监测其含量对于保证CP 的有效性十分重要。本文将就环磷酰胺的化学稳定性及常用含量测定方法作一介绍。
Since 1957 by Arnold and other synthetic cyclophosphamide (hereinafter referred to as CP), has been widely used as anti-tumor drugs in clinical, this product has a temporary tumor shrinkage, reduce patient pain, improve appetite and enhance physical function. In recent years, CP for some non-neoplastic diseases such as rheumatoid arthritis, systemic lupus erythematosus treatment also achieved some effect. In addition, CP can be used as an immunosuppressive agent for organ transplantation. However, since CP is highly hydrolyzable and hydrolyzate has no anti-tumor activity, it is important to monitor its content to ensure the effectiveness of CP. This article will be on the chemical stability of cyclophosphamide and the determination of commonly used methods for an introduction.