报告1例皮损广泛分布的泛发型穿通性环状肉芽肿.患者男,52岁.腹部、背部、臀部及四肢泛发红色丘疹3个月.组织病理上可见栅栏样肉芽肿及变性的组织经皮穿出.结合临床和组织病理诊断为泛性型穿通性环状肉芽肿.给予羟氯喹200 mg,每日2次口服,配合外用糖皮质激素制剂治疗,皮损略有好转,但治疗效果不理想.“,”A case of generalized perforating granuloma annulare(PGA) is reported.A 52-year-old male presented with asymptomatic generalized red papules on the abdomen,back,hips and extremities for 3 months.Histopathologic examination demonstrated palisading granulomas and degenerated tissue with transepidermal elimination.Coupled with clinical and histopathological features,the diagnosis of generalized PGA was made.Treatments with oral hydroxychloroquine 400 mg/d and topical corticosteroids slightly improved the lesion,but the outcome was unsatisfactory.