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报告1例肝移植术后Merkel细胞癌.患者女,64岁.因左颧部皮损4个月,增大2个月就诊.患者自诉肝硬化病史4年,3年前行肝脏移植手术.其母有肝硬化病史.皮肤科检查:左侧颧部一3.0 cm×2.5 cm紫红色圆顶状结节,基底浸润,触之较韧,表面光滑.皮损组织病理检查:真皮全层及横纹肌束间团块状基底样小细胞增生,增生细胞核深染,胞质稀少.免疫组化检查:嗜铬素(Cg)A、突触素(Syn)、细胞角蛋白(CK)20、CK18及广谱角蛋白(CKpan)均(+),增殖核抗原(Ki-67)40％+;CK7、melan-A、高分子角蛋白(CKH)及白细胞共同抗原(LCA)均(-).诊断:Merkel细胞癌.“,”A case of Merkel cell carcinoma after liver transplantation is reported.A 64-year-old female presented with a tumor on the left zygomatic area for 4 months and aggravated for 2 months.The patient claimed having a 4-year history of liver cirrhosis,and received liver transplantation three years ago.Her mother had a history of liver cirrhosis,too.Physical examination showed a firm,purple dome-shaped nodule sized 3.0 cm × 2.5 cm,with infiltrated base and smooth surface,on the left zygomatic area.Histopathological examination showed basaloid cell hyperplasia in the dermis and between the bundles of striated muscle.The proliferating cells were with darkly stained nuclei and sparse cytoplasm.Immunohistochemistry demonstrated tumor cells were positive for CgA,Syn,CK20,CK18,CKpan and Ki-67(40％),and negative for CK7,melan-A,CKH and LCA.The diagnosis was Merkel cell carcinoma.