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目的:评价七元瓜环对小鼠安全药理学,为后续研究瓜环类化合物对人体的影响以及作为新型药物辅料的开发提供基础资料数据。方法:依据中药、天然药物急性毒性研究技术指导原则的有关要求和OECD新发布急性径口毒性实验方法的有关记载,采用改良寇式法,计算出七元瓜环LD_(50)值。结果:七元瓜环LD_(50)值为49.1g/Kg。结论:七元瓜环属于无毒安全级,可作为一种新型安全、低毒的超分子药物载体,应用于超分子化学领域中。
OBJECTIVE: To evaluate the safety pharmacology of Qiyuanliu ring on mice and provide the basic data for the follow-up study on the effects of melonoids on human body and the development of new drug excipients. Methods: Based on the relevant requirements of the technical guidelines for acute toxicity study of traditional Chinese medicine and natural medicine and the new OECD test method for acute trail toxicity, the LD_ (50) value of seven-ring melon ring was calculated by the improved koala method. Results: The value of LD_ (50) of melon ring was 49.1g / Kg. Conclusion: The seven-membered melon ring belongs to the non-toxic safety class and can be used as a new safe and low-toxic supramolecular drug carrier in the field of supramolecular chemistry.