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为研究胎盘微绒毛膜铁蛋白受体（胎盘ＦｎＲ）在母－胎间铁代谢中的作用，用放射配体结合分析法测定２５例足月孕妇胎盘ＦｎＲ。其中，１１例正常孕妇胎盘ＦｎＲ数为（３．５３４±１．１０５）×１０１２位点·ｍｇ－１·ｐｒｏ－１，亲和常数为（３．２０３±０．６２２）×１０７·ｍｏｌ－１·Ｌ－１；１４例轻度缺铁性贫血（ＩＤＡ）孕妇胎盘ＦｎＲ数为（８．９３６±２．４０７）×１０１２位点·ｍｇ－１·ｐｒｏ－１，为正常孕妇的２．５３倍。此结果显示，人胎盘微绒毛膜上有大量胎盘ＦｎＲ表达，其数量随孕母铁营养状况而变化。提示胎盘ＦｎＲ介导铁转运是母－胎间铁的转运机制之一。轻度ＩＤＡ时，胎盘ＦｎＲ与配体结合的亲和常数稍低于正常，推测铁缺乏者ＦｎＲ构型可能有改变。
In order to study the role of placental microvillioferrin receptor (placental FnR) in maternal-fetal iron metabolism, placental FnR in 25 full-term pregnant women was determined by radioligand binding assay. Among them, the placental FnR number was (3.534 ± 1.105) × 1012 · mg-1 · pro-1 and the affinity constant was (3.203 ± 0.622) × 107 · mol- 1 · L-1. The FnR number of placenta of 14 mild IDA patients was (8.936 ± 2.407) × 1012 · mg-1 · pro-1, which was 2 of normal pregnant women. 53 times. The results showed that a large number of human placenta microvilli placenta FnR expression, the number changes with the nutritional status of maternal iron. Prompt placental FnR-mediated iron transport is one of the mother-child iron transport mechanism. At mild IDA, the affinity constant of placental FnR binding to the ligand is slightly below normal, suggesting that the FnR conformation may be altered in patients with iron deficiency.