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以脊髓灰质炎病毒（以下简称脊灰病毒）为载体构建的重组体活病毒可以做为探讨脊灰病毒的抗原结构和特性的有益手段。在构建重组有甲型肝炎病毒小片段抗原多肽的重组脊灰病毒基础上，分析了脊灰病毒VP1上中和抗原位点I的空间构象特点，并探讨了插入的外源抗原片段对其空间结构的可能影响。
Recombinant live virus constructed with poliovirus (hereinafter referred to as poliovirus) can be used as a useful tool to explore the antigenic structure and characteristics of poliovirus. Based on the construction of a recombinant poliovirus with the recombinant hepatitis A virus small fragment antigen polypeptide, the spatial conformation characteristics of neutralizing antigenic site I of VP1 of poliovirus were analyzed and the effect of inserted foreign antigen fragment on its space The possible effects of the structure.