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神经干细胞(ｎｅｕｒａｌ ｓｔｅｍ ｃｅｌｌ ＮＳＣ)是具有高度自我更新能力和多向分化潜能的神经前体细胞;利用含生长因子的培养基可从脑组织中分离并培养ＮＳＣ,通过基因修饰的方法还可建立细胞系。Ｎｅｓｔｉｎ是最常应用于鉴定ＮＳＣ的细胞特异性标志抗原;ＮＳＣ的增殖分化受基因和微环境内外双重机制的调控。目前的研究已经发现有多个基因及许多生长因子能调节ＮＳＣ的增殖并决定其分化方向;ＮＳＣ的应用主要集中在细胞替代治疗和基因(药物)载体两方面,其应用前景十分诱人。
Neural stem cell (NSC) is a neural progenitor cell with a high degree of self-renewal ability and multidirectional differentiation potential. NSC can be isolated and cultured from brain tissue using a growth factor-containing medium. Gene modification can also be used to establish Cell line. Nestin is the most commonly used cell-specific marker antigen for NSC identification. The proliferation and differentiation of NSC are regulated by both the internal and external mechanisms of genes and microenvironments. The current research has found that there are multiple genes and many growth factors can regulate the proliferation of NSC and determine the direction of its differentiation; NSC applications are mainly concentrated in the cell replacement therapy and gene (drug) vectors in two aspects, its application prospect is very attractive.