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实验选用成年大鼠 ,腹腔注射戊巴比妥钠麻醉 ,以膈神经放电为指标 ,分别观察了在前包钦格复合体(pre B¨otzingercomplex ,pre B¨ot复合体 )内微量注射兴奋性氨基酸 (红藻氨酸 ,KA ;L 谷氨酸 ,Glu)和抑制性氨基酸(甘氨酸 ,Gly ;γ 氨基丁酸 ,GABA)对呼吸活动的影响。在pre B¨ot复合体内注射KA后 ,所有动物首先出现呼吸兴奋效应 ,表现为吸气时程 (TI)延长 ,呼气时程 (TE)缩短 ,呼吸频率 (RF)增快 ;随后出现呼吸抑制效应 ,表现为呼吸停止于呼气状态。Pre B¨ot复合体内注射Glu ,引起动物TE 缩短 ,注射Gly或GABA均引起动物TI 缩短。这些结果表明 ,成年大鼠pre B¨ot复合体参与节律性呼吸活动的产生和调控 ,它可能是启动和维持吸气过程的中枢结构。
In the experiment, adult rats were anesthetized by intraperitoneal injection of pentobarbital sodium, and the excitability of microinjection in pre B¨|otinger complex (pre B¨¨ot complex) was observed with phrenic nerve discharge as an indicator Effects of amino acids (kainic acid, KA; L-glutamic acid, Glu) and inhibitory amino acids (glycine, Gly; γ-aminobutyric acid, GABA) on respiratory activity. After KA was injected into the pre B¨OT complex, all animals first developed respiratory excitatory effects with prolonged inspiratory time (TI), shortened expiratory time (TE), and increased respiratory rate (RF); subsequent respiration Inhibit effect, manifested as breathing stopped in exhaled state. Pre B¨ot complex injection of Glu, cause shortening of TE animals, animals injected with Gly or GABA caused shortening. These results indicate that the adult rat pre B¨ot complex is involved in the production and regulation of rhythmic respiration, which may be the central structure that initiates and maintains the inspiratory process.