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目的探讨慢性丙型肝炎肝组织病变与肝细胞凋亡的相互关系.方法采用免疫组化方法对比检测了30例慢性丙型肝炎患者肝组织中的FAS抗原(FASAG)和FAS配体(FASL)的表达.结果FASAG的表达主要在肝细胞浆,尤以邻近“碎屑样坏死”的淋巴细胞浸润区的肝细胞为甚,而FASL主要表达于炎症明显区的淋巴细胞.慢性丙型肝炎肝组织中FASAG和FASL表达的检出率分别为66?7％(20/30)和63?3％(19/30),FASAG和FASL表达阳性组的肝组织病变比阴性组严重;而且,随着组织炎症活动程度的加重其FASAG和FASL表达也明显增强(χ2分别为31?55和23?46,P＜0?01);此外,FASAG和FASL的表达与患者的性别无关(χ2分别为0?12和0?03,P＞0?05),与患者的年龄和血清ALT水平无关(T值分别为1?42和1?44,P＞0?05),但与血清总胆红素(TBIL)、清蛋白(A)、A/G和凝血酶原活动度(PTA)有关(T值分别为2?24和2?30,2?15和2?08,2?18和2?09,2?54和2?48,P＜0?05).结论CTL?FAS?FASL介导的肝细胞凋亡在慢性丙型肝炎肝组织的炎症“,”AIM To evaluate the role of Fas antigen (FasAg) and Fas ligand (FasL) and apoptosis in chronic hepatitis C. METHODS FasAg and FasL expressions were detected by immunohistochemical mothods in 30 liver samples from patients with chronic HCV infection. RESULTS The prevalence of FasAg and FasL expressions was 66 7%(20/30) and 63 3%(19/30) respectively. FasAg was mainly expressed in the cytoplasm of hepatocytes, especially among the nearly infiltrating lymphocytes of ''piecemeal necrosis''. FasL was mai...