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本文报告一例肛门鳞癌并发人类乳头瘤病毒(HPV)感染.患者男性,37岁,肛门边缘有一个大的肉样肿物,痒,偶有出血.活检显示为纤维上皮性息肉,具有尖圭湿疣的特征,同时有表面上皮的原位恶变和早期侵入性癌变,显然是一个发生自病毒性湿疣的鳞癌.由于这一发现,又将患者损害广泛切除.最后切除的组织中未发现不典型增生,但DNA杂交法对HPV16型为阳性,而对其他亚型如HPV6、11和18均为阴性.作者在讨论中指出,已报告HPV与宫颈和肛管
This article reports one case of anal squamous cell carcinoma complicated by human papillomavirus (HPV) infection. A 37-year-old male patient has a large, meaty mass on the verge of the anus, itch, and occasional hemorrhage. Biopsy reveals a fibroepithelial polyp, with sharp cues. The characteristics of genital warts, along with the in situ malignant transformation of surface epithelium and early invasive carcinogenesis, is clearly a squamous cell carcinoma that develops from viral genital warts. As a result of this discovery, the patient’s lesions were extensively resected. No tissue was found in the last excised tissue. Typical hyperplasia, but DNA hybridization was positive for HPV 16 and negative for other subtypes such as HPV 6, 11, and 18. The authors noted in the discussion that HPV has been reported with the cervix and anal canal.