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目的:探讨甲状腺自身免疫状态与131I治疗甲亢后早发甲减的关系。方法:对本院2006年1月～2008年6月收治的132例行131I治疗的甲亢患者,检测治疗前后三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、超敏促甲状腺激素刺激激素(sTSH)、摄碘率、甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(MCA)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺激素受体抗体(TRAb)。治疗后至少随访1年。用SPSS软件分析甲亢治疗后早发甲减与非早发甲减两组之间治疗前以上各项指标的差异。结果:早发甲减组治疗前TGAb、MCA、TPOAb水平高于非早发甲减组,差异有显著性。结论:TPOAb、TGAb和MCA是131I治疗甲亢后早发甲减的预测因子。
Objective: To investigate the relationship between thyroid autoimmune status and early hypothyroidism after 131I treatment of hyperthyroidism. Methods: A total of 132 patients with hyperthyroidism undergoing 131I treatment from January 2006 to June 2008 in our hospital were enrolled in this study. The levels of triiodothyronine (FT3), free thyroxine (FT4), hypersensitive thyroid stimulating hormone STSH, iodine uptake rate, thyroglobulin antibody (TGAb), thyroid microsomal antibody (MCA), thyroid peroxidase antibody (TPOAb) and thyrotropin receptor antibody (TRAb). Follow-up at least 1 year after treatment. SPSS software was used to analyze the differences of the above indexes before treatment between early hypothyroidism and non-early hypothyroidism after hyperthyroidism treatment. Results: The levels of TGAb, MCA and TPOAb in the early-onset hypothyroidism group were higher than those in the non-early-onset hypothyroidism group, the difference was significant. Conclusion: TPOAb, TGAb and MCA are predictors of early hypothyroidism after 131I treatment of hyperthyroidism.