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观察消旋TJ0711长期给药对肾性高血压大鼠的血压、心率的影响及对心血管的保护作用。制备两肾一夹型肾性高血压大鼠模型(renal hypertensive rats,RHR),将血压升高4 kPa的大鼠随机分为消旋TJ071110、20及40 mg.kg 1剂量组、卡维地洛阳性对照组和模型组以及假手术组(n=10)。每日1次灌胃给药。每周测量给药前后的血压和心率。于6～8周尾部取血,测定血浆丙二醛(MDA)、肾素、血管紧张素II(Ang II)和内皮素-1(ET-1)含量;9周后取左心室测左心室重量指数(LVWI)和羟脯氨酸含量。给药4周后,TJ0711 40 mg.kg 1剂量组的血压较第1周给药前显著降低,该作用一直延续至实验结束。TJ0711 10、20及40 mg.kg 1剂量组血浆中MDA、肾素、Ang II和ET-1含量均显著低于模型组(P<0.05,P<0.01),LVWI和心肌羟脯氨酸含量有降低趋势。结果显示,TJ0711连续给药后使给药前的血压值持续下降,除了直接阻断肾上腺素α和β受体产生降压外,其持续降压作用与减少血浆中缩血管物质和氧化产物MDA有关,这有利于对心血管发挥保护作用。
To observe the effect of long-term administration of racemic TJ0711 on blood pressure and heart rate and its cardiovascular protective effect in renal hypertensive rats. Rats were randomly divided into racemic TJ071110, 20 and 40 mg.kg 1 dose groups. Carvedilol Luoyang control group and model group and sham operation group (n = 10). Gavage once daily. Weekly measurement of blood pressure and heart rate before and after administration. The blood samples were taken from the tail of 6-8 weeks, and the levels of malondialdehyde (MDA), renin, angiotensin II (Ang II) and endothelin-1 (ET- Weight index (LVWI) and hydroxyproline content. After 4 weeks of administration, the blood pressure of 1 dose group of TJ0711 40 mg.kg was significantly lower than that of the 1st week before administration, and the effect continued until the end of the experiment. The levels of MDA, renin, Ang II and ET-1 in the TJ0711 10, 20 and 40 mg.kg 1 groups were significantly lower than those in the model group (P <0.05, P <0.01), LVWI and hydroxyproline There is a downward trend. The results showed that continuous administration of TJ0711 after administration of blood pressure values continued to decline, in addition to directly blocking the adrenaline α and β receptors produce antihypertensive, sustained antihypertensive effect and reduce the plasma vasoconstrictor substance and the oxidation product MDA Related, which is conducive to cardiovascular protection.