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目的探讨系膜增生性肾小球肾炎(MsPGN)患儿血浆、尿液转化生长因子_β1(TGF_β1)检测的临床意义。方法应用酶联免疫吸附法(ELISA)测定30例MsPGN,并对照观察30例轻微病变(ML)、24例局灶节段性肾小球硬化(FSGS)和30例对照组儿童血浆、尿液中的TGF_β1水平。结果MsPGN组血浆、尿液中TGF_β1水平与对照组比较,差异无显著性(P>0.05);与FSGS组比较差异有非常显著性(P<0.01)。MsPGN组TGF_β1水平与系膜增生程度、间质炎症细胞浸润及蛋白尿严重程度相关。结论血浆、尿液中TGF_β1检测可间接反映MsPGN的病情严重程度,对估计MsPGN严重程度及进展有一定的临床意义。
Objective To investigate the clinical significance of detection of transforming growth factor-β1 (TGF-β1) in plasma and urine of children with mesangial proliferative glomerulonephritis (MsPGN). Methods Thirty cases of MsPGN were detected by enzyme-linked immunosorbent assay (ELISA). Thirty cases of mild lesions (ML), 24 cases of focal segmental glomerulosclerosis (FSGS) and 30 controls were observed in children with plasma and urine In the TGF_β1 levels. Results The levels of TGF-β1 in plasma and urine of MsPGN group were not significantly different from those in control group (P> 0.05). There was significant difference between the two groups (P <0.01). The level of TGF_β1 in MsPGN group was related to the mesangial proliferation, interstitial inflammatory cell infiltration and proteinuria severity. Conclusion The detection of TGF-β1 in plasma and urine can indirectly reflect the severity of MsPGN, which has some clinical significance in estimating the severity and progression of MsPGN.