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目的 :研究小儿咳喘冲剂的止咳、平喘、祛痰作用。方法 :采用豚鼠整体引喘法及豚鼠离体气管法观察小儿咳喘冲剂的平喘作用 ;用电刺激猫喉上神经引咳法及氨水刺激小鼠引咳法观察该药的镇咳作用 ;用小鼠酚红实验观察其祛痰作用。结果 :该药可以有效地降低动物由电及氨水刺激引咳的咳嗽次数 ,可以明显延长豚鼠致喘的潜伏期 ,使乙酰胆碱及组胺造成的豚鼠离体气管收缩幅度降低 5 2 .0 %和 18.5 % ;可以增加小鼠气管及支气管酚红的分泌量。结论 :小儿咳喘冲剂具有较好的止咳、平喘、祛痰效果
Objective : To study the antitussive, antiasthmatic and expectorant effects of Xiaoke Kechuan Granules. METHODS: The anti-asthmatic effect of Xiaoke Kechuan Granules was observed by guinea pig whole induced asthma method and in vitro trachea method of guinea pigs. The antitussive effect of Xiaoke Cough Granules was stimulated by electrical stimulation of the cough method of cats’ superior laryngeal nerve and the cough induced by ammonia in mice. Experiment with mouse phenol red to observe the effect of its limulus. Results: The drug can effectively reduce the number of coughs induced by electroporation and ammonia stimulation in animals. It can prolong the incubation period of guinea pigs and reduce the contraction amplitude of guinea pigs caused by acetylcholine and histamine by 52.0 % and 18.5. %; can increase the secretion of phenol red in the trachea and bronchi of mice. Conclusion : Xiaoke Kechuan Granules have good antitussive, antiasthmatic and expectorant effects