原发性醛固酮增多症于1955年由Conn氏首先所描述。由于醛因酮分泌的增多继而产生高血压、低血钾和代谢性碱中毒。临床多表现为肌无力、多喝多尿,以及低钾所导致的肾病变。作者在1964年治疗9例原发性醛固酮增多症,其分析如下: 病史和体征:9例中男5例女4例,年龄在26～61岁之间。高血压时间5个月——20年,其中5例高血压病史超过10年。表现头痛者5例,肌无力8例,烦渴多尿4例。体征多为高血压,表现Kimmcltiel-Wilson高血压眼底变化。3例心脏中等度扩大。化验:每个病例电解质变化与诊断是一致的。血钾极度减低(最低者为1.7毫克当量/升),高血钠(最高为148毫克当量/升),二氧化碳结合力值是高的(最高值39.7毫克当量/升)。6例中3例唾液钾与钠比例大于1。7例进行了尿醛固酮的测定,其中4例高于正常(最高达190微克/24小时)。6例作了周围血肾素的测定其中5例低于正常。X光检查对确诊和腺瘤定位帮助不大。全部 Primary aldosteronism was first described by Conn in 1955. Due to the increased secretion of aldehydes, hypertension, hypokalemia, and metabolic alkalosis are subsequently produced. Most of the clinical manifestations of muscle weakness, drink plenty of urine, and kidney disease caused by low potassium. The authors treated 9 cases of primary aldosteronism in 1964. The analysis was as follows: History and signs: 9 cases were male and 5 cases were female, aged between 26 and 61 years old. The duration of hypertension was 5 months to 20 years, of which 5 cases had a history of hypertension over 10 years. There were 5 cases of headache, 8 cases of muscle weakness, and 4 cases of polydipsia. Signs are mostly high blood pressure, showing Kimmcltiel-Wilson hypertension eye changes. In 3 cases, the heart expanded moderately. Laboratory tests: The electrolyte changes and diagnosis were consistent in each case. Hyperkalemia was extremely reduced (lowest 1.7 meq/l), hypernatremia (maximum 148 meq/l), and carbon dioxide binding force was high (maximum value 39.7 meq/l). Three of six patients had a potassium-sodium ratio of greater than 1. The urine aldosterone was measured in 7 patients, 4 of which were higher than normal (up to 190 μg/24 hours). In 6 patients, peripheral renin was measured and 5 of them were lower than normal. X-ray examination is not helpful for diagnosis and adenoma localization. All