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米索前列醇又被称做喜克溃,是一种人工合成的前列腺素E1的类似物,在临床上用途广泛,在上世纪80年代米索前列醇被首先发现能够用于治疗消化性溃疡的患者,在上世纪80年代以后米索前列醇被运用于妇产科,在早期研究中发现可以导致完全流产的几率从而被用于抗早孕的治疗。在最近的研究中发现该药在临床能够广泛应用,在诸如人工流产、诊断性刮宫、节育器的放置与摘除、术前或口服性阴道给药、扩张宫颈、降低患者手术痛苦等方面有着不同数量的记载。米索前列腺醇施用在引产中期的患者中可增加药物引产的效果,对于死胎的引产效果能够达到完全成功,在足月妊娠的患者中能够诱发宫缩并缩短产程。米索前列醇能够促进机体宫颈发育、诱导患者分娩、降低剖宫产术后出血几率,而在临床中不同的给药途径能够获得不同的治疗效果,该药口服的吸收速度最高,仅0.5h就能达到血药浓度峰值,在人体中血浆清除的半衰期可达1.5h,在局部用药具有副反应小、吸收快的特点,能够直接对宫颈产生作用。米索前列醇使用方法简便、临床效果有保证、具有安全性、副反应强度低、价格低廉等优势,在各级医院尤其是基层医院的临床诊疗中具有重要的作用,在降低患者产后出血的发生概率,减少孕妇产后死亡的可能性等方面治疗都具有十分重要的作用。
Misoprostol, also known as cicloprost, is a synthetic analogue of prostaglandin E1 that has been used clinically for a number of reasons. It was first discovered in the 1980s that misoprostol was first used to treat peptic ulcer disease Of patients, misoprostol was used in obstetrics and gynecology after the 1980s, and in early studies it was found that the chances of causing a complete abortion could be used to treat early pregnancy. In recent studies, it has been found that the drug is widely used clinically, and has different clinical applications such as abortion, diagnostic curettage, placement and extirpation of IUDs, preoperative or oral vaginal administration, cervical dilatation, and reduction of surgical pain. The number of records. Misoprostol administration increases the effects of drug abortion in mid-abortion patients, achieves complete success with induction of labor on stillbirths, and induces uterine contractions and shortens labor during term pregnancy. Misoprostol can promote the development of the body’s cervix, induce the delivery of patients and reduce the chance of bleeding after cesarean section. Different routes of administration in the clinic can achieve different therapeutic effects. The oral absorption rate of the drug is highest at only 0.5h Can reach the peak plasma concentration in the human body half-life of plasma clearance up to 1.5h, with side effects in the local drug with small, fast absorption characteristics, can have a direct effect on the cervix. Misoprostol is easy to use, with guaranteed clinical effect, safety, low side reaction intensity, low price and other advantages. It has an important role in the clinical diagnosis and treatment of all levels of hospitals, especially the primary hospitals. It can reduce postpartum hemorrhage The probability of occurrence, the possibility of reducing the postpartum death of pregnant women and so on, all play an important role.