胶原病属结缔组织疾病,易侵犯全身血管系统,并可损及中枢神经及周围神经。一、全身性红斑狼疮本病好发于15～40岁,以女性为多。颊部、鼻梁处常有蝶形红斑,颈部、手足末端亦可发生皮疹。疾病初期神经病变发生率为25％,在病程经过中可达60％左右,以中枢神经损害为多。神经病变之临床表现有: 1.精神障碍:最常见,其发生率在精神科作者的报告为49～52％,非精神科的 Collagen disease is a connective tissue disease, easy to infringe the systemic vascular system, and can damage the central nervous and peripheral nerves. First, systemic lupus erythematosus The disease occurs in 15 to 40 years old, more women. Buccal, nasal bridge often erythema, neck, hand-foot end can also occur rash. The incidence of neurological disease early 25%, after the course of up to 60%, to more damage to the central nervous system. The clinical manifestations of neuropathy are: 1. Mental disorders: The most common, the incidence of psychiatry in the report of 49 to 52%, non-psychiatric