放射性间质性肺炎 (radiationinterstitialpneumonia ,RIP)是临床上胸部肿瘤放疗、骨髓移植预处理及平时核辐射事故、战时辐射损伤后常见的一种并发症。尽管人们从各种角度对其进行了研究 ,也提出了许多观点 ,但迄今为止其发病机理仍然未被完全阐明。本文归纳总结了目前人们趋于接受的三种关于RIP发病机理的学说 ,即肺实质细胞靶细胞学说、肺间质浸润细胞参与学说与细胞因子介导学说 ,期望对该病的研究与临床治疗提供一些借鉴。 Radiation interstitial pneumonia (radiationinterstitialpneumonia, RIP) is a common complication after radiotherapy of chest cancer, pretreatment of bone marrow transplantation and normal nuclear radiation accidental radiation injury after wartime. Although many people have studied and put forward many points of view from various angles, the pathogenesis of so far has not yet been fully elucidated. This article summarizes the three currently accepted doctrines on the pathogenesis of RIP, that is, the theory of target cells of lung cells, lung interstitial cells involved in the theory and cytokine-mediated theory, looking forward to the study and clinical treatment of the disease Provide some reference.