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营养低下是外科病人的常见问题,对体液和细胞免疫均有广泛的影响,包括细胞吞噬作用受损和补体水平下降.已经证明,急性饥饿时网状内皮系统(RE)对细菌及微粒物质的清除受损.营养不良引起RE抑制的机理尚未明确,可能包括调理素作用不足,内在的吞噬细胞功能衰竭及肝脏血流改变.血浆纤维结合素是重要的RE非特异性调理素,可防止细菌及败血症产物播散入循环,从而导致全身性不良后果和器官衰竭.作者使用兔模型研究禁食、手术创伤和感染对血浆纤维结合素和RE功能的影响.禁食时间为48小间,通过结扎离断兔阑尾血管导致腹膜炎而建立感染模型.血浆纤维结合素的测定采用免疫比浊法,用
Undernutrition is a common problem in surgical patients and has widespread effects on both humoral and cellular immunity, including impaired cell phagocytosis and decreased complement levels. It has been demonstrated that the reticuloendothelial system (RE) in acute starvation affects both bacterial and particulate matter The mechanism of RE inhibition due to malnutrition is unclear and may include the effects of opsonization, intrinsic phagocyte depletion and changes in hepatic blood flow.Plasma binding is an important RE non-specific opsonin that prevents bacterial and / Sepsis products spread throughout the circulation, leading to systemic adverse consequences and organ failure.The authors used a rabbit model to study the effects of fasting, surgical trauma and infection on plasma fibronectin and RE function. Fasting time was 48 hours, The model of infection was established by cutting off the blood vessels of rabbit’s appendix and the peritonitis was established.The plasma fibronectin was determined by immunoturbidimetry,