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本文研究了阿斯匹林缓释片的处方组成制备工艺,采用转蓝法研究了阿斯匹林缓释片与普通片的体外溶出速率。数据按威布尔分布模型求得 T_(50)、Td、m 值等参数。将两种制剂的 T_(50)、Td 分别进行方差分析,结果有显著性差异。表明以乙基纤维素为缓释材料所制得的阿斯匹林缓释片具有缓释作用。
In this paper, aspirin sustained-release tablets prescription composition preparation process, using turn blue method aspirin sustained-release tablets and tablets in vitro dissolution rate. The data obtained by Weibull distribution model T_ (50), Td, m value and other parameters. The two formulations of T_ (50), Td were analyzed by ANOVA, the results were significantly different. Aspirin sustained-release tablets prepared with ethylcellulose as sustained-release materials showed sustained release.