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目的研究Cyr61和Survivin在宫颈癌组织中表达的相关性。方法应用免疫组织化学MaxVisionTM法检测Cyr61、Survivin在20例正常宫颈组织、48例宫颈癌组织中的表达情况。结果 Cyr61、Survivin在宫颈癌组织中阳性表达率分别为41.67%、79.17%。在宫颈癌中,Cyr61的表达与Survivin的表达呈负相关(rs=-0.501,P=0.000)。结论在宫颈癌中,Cyr61表达与Survivin表达呈负相关。提示Cyr61表达可能通过诱导肿瘤细胞的凋亡,起到类似抑癌基因的作用。
Objective To study the expression of Cyr61 and Survivin in cervical cancer. Methods The expression of Cyr61 and Survivin in 20 cases of normal cervical tissues and 48 cases of cervical cancer tissues were detected by MaxVisionTM immunohistochemistry. Results The positive rates of Cyr61 and Survivin in cervical cancer tissues were 41.67% and 79.17% respectively. In cervical cancer, Cyr61 expression was negatively correlated with Survivin expression (rs = -0.501, P = 0.000). Conclusion In cervical cancer, the expression of Cyr61 is negatively correlated with the expression of Survivin. It is suggested that Cyr61 expression may play a similar role of tumor suppressor gene by inducing tumor cell apoptosis.