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目的:分析甲氧氯普胺(胃复安)致锥体外系反应的规律和特点。方法:检索1994年1月～2008年12月国内医药学期刊,收集胃复安致锥体外系反应79例病例,应用文献计量学方法对病例进行整理与归纳。结果:除两例发生1种ADR,其他病例均出现两种及以上ADR,共发生258例次。临床主要表现有头后仰、颈部强直54例次(20.9%),眼上翻或凝视47例次(18.2%),发音困难或构音不清21例次(8%),肢体震颤或抽搐20例次(7.8%),男女无明显区别,随着年龄增大,ADR患者比例逐渐降低。ADR产生与药物吸收快慢,吸收呈正相关。结论:临床上应重视胃复安致锥体外系反应,注意询问患者病史,防止误诊误治,同时注意控制给药量。
OBJECTIVE: To analyze the regularity and characteristics of extracerebral reaction induced by metoclopramide (metoclopramide). Methods: A total of 79 cases of pyruvate-induced extrapyramidal reactions were collected from January 1994 to December 2008 in domestic medical journals. The cases were summarized and summarized by using bibliometric method. Results: Except one ADR occurred in two cases, two or more ADR occurred in other cases, a total of 258 cases occurred. There were 54 patients (20.9%) with ankylosis of the neck, 47 cases (18.2%) turned or stared, 21 cases (8%) had dysarthria or dysarthria, tremor or Convulsions 20 cases (7.8%), no significant difference between men and women, with age, the proportion of ADR patients gradually decreased. ADR production and drug absorption speed, absorption was positively correlated. Conclusion: We should attach great importance to the clinical response to metoclopramide extrapyramidal reactions, pay attention to ask the patient’s medical history, to prevent misdiagnosis and mistreatment, while paying attention to control the dosage.