经蝶窦垂体瘤切除术的历史证实了经鼻进入蝶鞍这个基本概念的正确性。1910年到1925年期间,库兴在唇下经中隔蝶窦入路作了231例垂体腺瘤切除术,死亡率仅5.6％,结果很好,库兴放弃了这一技术。因为进路狭窄,显露肿瘤困难,不易切除向鞍上发展的肿瘤部分。因此,在1920年至1960年期间多数垂体瘤仍经颅手术。 The history of transsphenoidal pituitary tumor resection confirmed the correctness of the basic concept of nasal entry into the sella. From 1910 to 1925, Kuching had 231 cases of pituitary adenoma resection through the sphenoid sinus approach under the lip. The mortality rate was only 5.6%. The results were very good. Kuxing gave up this technique. Because of the narrow approach, it is difficult to expose the tumor and it is not easy to remove the part of the tumor that has developed on the saddle. Therefore, most pituitary tumors were still transcranially operated between 1920 and 1960.