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目的：探讨不同严重程度的胰腺炎时血清总淀粉酶及淀粉酶同工酶活性变化的规律。方法：建立急性水肿型及急性出血坏死型胰腺炎的动物模型，观察淀粉酶及同工酶的变化。结果：在急性水肿型胰腺炎组中，血清胰淀粉酶的增高与胰腺炎严重程度呈正相关；在坏死型胰腺炎组中，随着胰腺坏死程度的加重，血清总淀粉酶活性下降至正常对照组的１．５倍左右，但血清胰淀粉酶活性仍在正常对照组的５倍以上。结论：急性水肿型胰腺炎时，血清总淀粉酶及胰淀粉酶活性可反映炎症水肿的程度；坏死型胰腺炎时，测定血清胰淀粉酶较测定血清总淀粉酶活性更有效。
Objective: To investigate the changes of total amylase and amylase isoenzyme in serum of patients with different severity of pancreatitis. Methods: Animal models of acute edema and acute hemorrhagic necrosis were established and the changes of amylase and isoenzyme were observed. Results: In acute edematous pancreatitis group, the increase of serum pancreatic amylase was positively correlated with the severity of pancreatitis. In necrotizing pancreatitis group, the total amylase activity of serum decreased to normal control Group 1.5 times, but serum pancreatic amylase activity is still more than 5 times the normal control group. Conclusion: In acute edematous pancreatitis, the serum total amylase and pancreatic amylase activity can reflect the degree of inflammatory edema. In necrotic pancreatitis, the determination of serum pancreatic amylase is more effective than the determination of serum total amylase activity.