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目的研究非甾体类抗炎新药—ＮＪ９６７的抗炎作用。方法采用角叉菜胶诱导的大鼠急性足爪肿胀模型和福氏完全佐剂诱导的大鼠佐剂性关节炎模型。结果ＮＪ９６７２５，５０，１００ｍｇ·ｋｇ－１灌胃给药可明显抑制大鼠急性足爪肿胀，其半数抑制量（ＩＤ５０）为７６ｍｇ·ｋｇ－１；该剂量的ＮＪ９６７预防与治疗给药，每天灌胃１次，连续７天亦可抑制大鼠佐剂性关节炎继发性足爪肿胀。结论ＮＪ９６７具有较强的抗炎作用。
Objective To study the anti-inflammatory effect of non-steroidal anti-inflammatory drug-NJ967. Methods Carrageenan-induced rat acute paw swelling model and Freund’s complete adjuvant induced rat adjuvant arthritis model. Results Administration of NJ96725 at doses of 50 and 100 mg · kg-1 could significantly inhibit the swelling of acute paw in rats with a median inhibitory concentration (ID50) of 76 mg · kg-1. Administration of NJ967 at this dose of prophylaxis and treatment dosed daily Stomach 1, 7 consecutive days can also inhibit the secondary swelling of adjuvant arthritis in rats. Conclusion NJ967 has a strong anti-inflammatory effect.