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目的:探讨膀胱尿路上皮癌中MHC Ⅰ类链相关蛋白A(MICA)的表达及临床意义。方法:用免疫组化检测75例膀胱尿路上皮癌及15例正常膀胱黏膜中MICA蛋白表达,对MICA蛋白在膀胱黏膜、不同级别及分期的膀胱癌中的表达进行统计学分析。结果:MICA蛋白在膀胱癌的表达率(48.0%)高于正常膀胱黏膜(P<0.05),其中在非浸润性尿路上皮癌的表达率为59.0%(P<0.05),浸润性36.1%;高、低级别非浸润性癌MICA蛋白表达无统计学意义;MICA蛋白在Ta、T1和T2~4期膀胱癌的表达率分别为59.0%、41.2%和31.6%,MICA蛋白在浸润性膀胱癌(T1~4)的表达低于非浸润性膀胱癌(Ta)(P<0.05)。结论:MICA蛋白表达上调可能与膀胱尿路上皮癌的发生有关,而MICA蛋白表达缺失可能与膀胱癌的浸润有关。MICA蛋白可作为膀胱癌免疫治疗的侯选治疗靶点。
Objective: To investigate the expression of MHC class Ⅰ chain associated protein A (MICA) in bladder urothelial carcinoma and its clinical significance. Methods: MICA protein expression was detected by immunohistochemistry in 75 cases of bladder urothelial carcinoma and 15 cases of normal bladder mucosa. The expressions of MICA protein in bladder mucosa, different grades and stages of bladder cancer were statistically analyzed. Results: The expression of MICA protein in bladder cancer was higher than that in normal bladder mucosa (48.0%, P <0.05). The positive rate of MICA protein in non - invasive urothelial carcinoma was 59.0% (P <0.05) . The expression of MICA protein in high and low grade non-invasive cancer was not statistically significant. The expression rates of MICA protein in Ta, T1 and T2 ~ 4 bladder cancer were 59.0%, 41.2% and 31.6%, respectively. MICA protein expression in invasive bladder The expression of cancer (T1 ~ 4) was lower than that of non-invasive bladder cancer (P <0.05). Conclusion: The up-regulation of MICA protein may be related to the occurrence of bladder urothelial carcinoma, while the loss of MICA protein may be related to the invasion of bladder cancer. MICA protein can be used as a candidate therapeutic target for bladder cancer immunotherapy.