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目的探讨不同运动负荷的游泳训练对 SD大鼠心血管内分泌功能的影响。方法雄性 SD大鼠分为 4组，进行 8周的游泳训练，用放射免疫法测定大鼠血浆和心肌细胞中内皮素 (ET)、血管紧张素Ⅱ (AGTⅡ )含量及心肌细胞膜上受体 (ETR)活性的影响。结果 90min组大鼠血浆和心肌细胞中 ET和 AGTⅡ都比对照组有明显降低 (P< 0.01)，且可下调 ETR的数量和亲和力 (P< 0.01)。 150min组血浆中 AGTⅡ明显高于对照组 (P< 0.01)；心肌细胞膜上 ETR的 Kd值明显低于对照组 (P< 0.01)。结论中等负荷的运动可明显改善心血管系统的功能，而负荷较大的运动对心血管系统功能的改善不利。
Objective To investigate the effects of swimming training with different exercise load on cardiovascular endocrine function in SD rats. Methods Male Sprague-Dawley rats were divided into 4 groups and trained for 8-week swimming. The content of ET, AGTⅡ and the level of the receptor on the membrane of myocardium were measured by radioimmunoassay ETR) activity. Results The levels of ET and AGTⅡ in plasma and cardiomyocytes in 90min group were significantly lower than those in control group (P <0.01), and the number and affinity of ETR were decreased (P <0.01). The plasma level of AGTⅡ in 150min group was significantly higher than that in control group (P <0.01). The Kd value of ETR in myocardial cell membrane was significantly lower than that in control group (P <0.01). Conclusion Moderate-load exercise can significantly improve the cardiovascular system function, while exercise with greater load adversely affects cardiovascular system function.