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目的比较氯吡格雷与阿司匹林对缺血性脑血管病患者再次发生缺血事件的影响。方法 150例脑梗塞和短暂性脑缺血发作(TIA)患者随机分入肠溶阿司匹林组(100mg,1次/d,80例)及氯吡格雷组(75mg,1次/d,70例),观察两组脑缺血事件发生率。结果氯吡格雷组脑梗塞和TIA的发生率(6.1%)低于阿司匹林组(x2=26.7%,P<0.05);且TIA发展为脑梗塞的患者比例有减少的趋势;出血并发症发生率(氯吡格雷组7.14%,阿司匹林组7.50%)差异无统计学意义(P>0.05)。结论氯吡格雷预防缺血性脑血管病再发的效果优于阿司匹林,且并未增加出血并发症,总体安全性至少与后者相同。
Objective To compare the effects of clopidogrel and aspirin on recurrent ischemic events in patients with ischemic cerebrovascular disease. Methods A total of 150 patients with cerebral infarction and transient ischemic attack (TIA) were randomly divided into two groups: the aspirin group (n = 100) and the clopidogrel group (n = 75) , Observed the incidence of cerebral ischemia in two groups. Results The incidence of cerebral infarction and TIA in clopidogrel group (6.1%) was lower than that in aspirin group (x2 = 26.7%, P <0.05), and the proportion of patients with TIA developing cerebral infarction had a decreasing trend. The incidence of bleeding complication (7.14% in clopidogrel group and 7.50% in aspirin group) showed no significant difference (P> 0.05). Conclusion Clopidogrel is superior to aspirin in preventing recurrence of ischemic cerebrovascular disease without increasing hemorrhagic complications with at least the same overall safety.