将难溶性药物作成注射剂,除可采用各种促使难溶性药物溶解的方法如制成可溶性盐、引入可溶性基团、助溶、增溶等方法外,也可采用非水溶媒配制。当药物由于一些物理或化学的因素(例如一定限度的溶解度、水解反应等)而不能制成水性制剂时,采用非水溶媒常能制成稳定而适宜的注射剂。此种以非水溶媒制成的真溶液型注射液,可避免混悬液的缺点(如剂量不均匀、结块、作用缓慢和注射困难等)。例如氯 The insoluble drugs as injections, in addition to using a variety of methods to promote the dissolution of insoluble drugs such as soluble salt, the introduction of soluble groups, solubilization, solubilization and other methods, but also the use of non-aqueous solvent preparation. When a drug can not be made into an aqueous formulation due to a number of physical or chemical factors (for example, a limited degree of solubility, hydrolysis reaction, etc.), a non-aqueous vehicle can often be used as a stable and suitable injection. Such a solution of a true solution in the form of a non-aqueous vehicle avoids the disadvantages of the suspension (such as uneven dosage, agglomeration, slow effects, injection difficulties, etc.). For example chlorine