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血小板生长因子(PDGF)是一种无处不在的生长因子,它由A、B两链组成,是一种碱性的蛋白质,PI9.8～10,分子量30KDa。血小板生长因子受体是一种存在于细胞膜上的糖蛋白,由α、β两个亚基组成,PDGF与其相应受体结合发挥特有的生物学作用。PDGF不仅在正常体内起作用且与某些疾病密切相关。 1974年Ross等人发现血凝块或全血中存在有促进间充质细胞(如成纤维细胞等)分裂作用的物质,由于这种物质来源于血小板,故被定义为血小板生长因子,但是分泌血小板生长因子不只限于血小板,其它许多细胞如:某些赘生物或肿瘤细胞、血管内皮
Platelet-derived growth factor (PDGF) is a ubiquitous growth factor, which consists of A and B chains. It is a basic protein with a PI of 9.8-10 and a molecular weight of 30 kDa. Platelet-derived growth factor receptor is a glycoprotein present on the cell membrane. It consists of two subunits α and β. PDGF binds to its corresponding receptor and plays a specific biological role. PDGF not only works in normal body but also is closely related to certain diseases. In 1974 Ross et al. Found that blood clot or whole blood exists to promote the division of mesenchymal cells (such as fibroblasts, etc.) material, because this material is derived from platelets, it is defined as platelet growth factor, but secretion Platelet growth factor is not limited to platelets, many other cells such as: certain neoplasms or tumor cells, vascular endothelial