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目的观察人用无佐剂狂犬病疫苗的接种反应及免疫效果。方法使用无佐剂CTN-IV株Vero细胞疫苗和无佐剂AG株原代地鼠肾细胞疫苗免疫健康成人,按暴露后全程免疫程序接种,Vero细胞疫苗接种41人,地鼠肾细胞疫苗接种32人,观察其接种反应及免疫效果。结果接种人用无佐剂狂犬病疫苗后,无严重局部或全身不良反应出现。首剂免疫后14d,两组疫苗抗体阳转率均达100%,中和抗体滴度分别为7.29和6.35IU/ml,二者差异无显著意义。结论无佐剂狂犬病疫苗接种后无严重不良反应出现,且免疫效果良好。
Objective To observe the vaccination response and immune effect of human unadjuvanted rabies vaccine. Methods The naive murine renal cell vaccine was immunized with unadjuvanted CTN-IV strain Vero cell vaccine and unadjuvanted AG strain vaccine. The immunized rabbits were vaccinated with whole-body immunization program after exposure. Vero cell vaccine was vaccinated in 41 and hamster kidney cell vaccine 32 people observed the vaccination response and immune effect. Results No serious local or systemic adverse events occurred after vaccination with human unadjuvanted rabies vaccine. At the 14th day after the first dose of immunization, the antibody positive rate of both vaccines reached 100% and the neutralizing antibody titers were 7.29 and 6.35 IU / ml, respectively. There was no significant difference between the two groups. Conclusion No serious adverse reactions occurred after vaccination without adjuvant rabies vaccine, and the immune effect was good.