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齐墩果酸对CCl_4引起的大鼠急性肝损伤有明显的保护作用。表现在药物能使血清GPT明显下降;肝内甘油三酯蓄积量减少;肝细胞变性、坏死明显减轻,糖原蓄积增加;根据超微结构观察,肝细胞内线粒体肿胀与内质网囊泡变减轻。
Oleanolic acid has a significant protective effect on CCl_4-induced acute liver injury in rats. Manifested in the drug can make the serum GPT decreased significantly; liver triglyceride accumulation decreased; liver cell degeneration, necrosis significantly reduced, glycogen accumulation increased; according to ultrastructure observation, hepatocyte mitochondrial swelling and endoplasmic reticulum vesicle changes Reduce.