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目的研究儿童白血病发病风险与磁场暴露之间的关系。方法检索Pub Med、Pro Quest、SCI和Medline数据库,收集1997~2014年间发表的探究磁场暴露与儿童白血病发病关联性的病例对照研究。采用Stata 12.0软件对纳入文献进行Meta分析,包括异质性检验、评估文献发表偏倚、敏感性分析、合并效应量。结果最终纳入9篇文章,包括11 699例白血病患者和13 194例对照。Meta分析结果显示,与<0.1μT的磁场暴露水平相比较,≥0.4μT的磁场暴露水平与儿童白血病发病有关联(OR=1.58,95%CI=1.03~2.43);与<0.2μT的磁场暴露水平相比较,≥0.2μT的磁场暴露水平与儿童白血病发病有关联(OR=1.30,95%CI=1.06~1.61)。结论磁场暴露水平可能与儿童白血病发病有关。
Objective To study the relationship between the risk of childhood leukemia and magnetic field exposure. Methods The Pub Med, Pro Quest, SCI and Medline databases were searched and a case-control study of the association between exploratory magnetic field exposure and childhood leukemia published between 1997 and 2014 was collected. Stata 12.0 software was used to perform meta-analysis of the included literature, including tests for heterogeneity, assessing publication bias, sensitivity analysis, and co-efficacy. The results eventually included 9 articles, including 11 699 leukemia patients and 13 194 controls. Meta-analysis showed that magnetic field exposure ≥ 0.4 μT was associated with childhood leukemia (OR = 1.58, 95% CI = 1.03-2.43) compared to <0.1 μT magnetic field exposure; The level of magnetic field ≥0.2μT was correlated with the onset of childhood leukemia (OR = 1.30, 95% CI = 1.06-1.61). Conclusion Magnetic field exposure may be related to the pathogenesis of childhood leukemia.