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以每周定时im马桑内酯0.9～1.5mg/kg三个月为实验性癫痫慢性发作模型。ig芹菜甲素700mg/kg能明显降低大鼠癲痫发作的程度和次数,延长潜伏期。脑形态学结果表明,芹菜甲素对大脑顶叶皮层细胞、胶质细胞和小脑蚓部蒲肯野细胞有一定的保护作用。同时观察的安定1.5～5mg/kg则无此作用。
Tim weekly intramuscular 0.9 ~ 1.5mg / kg three-month experimental epilepsy model of chronic attack. ig celery A 700mg / kg can significantly reduce the extent and frequency of seizures in rats to extend the incubation period. Brain morphological results showed that celerychin had some protective effects on Purkinje cells in cerebellar parietal cortex, glial cells and cerebellar vermis. At the same time the observed stability of 1.5 ~ 5mg / kg is no such effect.