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目的:探讨弥散加权成像、1H磁共振波谱诊断新生儿缺氧缺血性脑病的应用价值。方法:以本院收治的缺氧缺血性脑病新生儿37例为研究组,另选择健康新生儿40例作为对照组,两组新生儿均接受弥散加权成像及1H磁共振波谱检查,观察研究组新生儿普通MRI与弥散加权成像检查结果,对比研究组和对照组新生儿的脑代谢化合物相对浓度。结果:与普通MRI检出率相比,研究组患儿的弥散加权成像信号明显升高,差异存在统计学意义(P<0.05)。研究组NAA/Cr比值低于对照组,Cho/Cr、MI/Cr、Glu-Gln/Cr、Lac/Cr比值高于对照组,差异存在统计学意义(P<0.05)。结论:临床上诊断新生儿缺氧缺血性脑病时,弥散加权成像与1H磁共振波谱的联合应用可提升诊断准确率,通过对代谢物浓度的分析有利于评价缺氧缺血导致脑组织损害的严重程度。
Objective: To investigate the value of diffusion-weighted imaging and 1H magnetic resonance spectroscopy in the diagnosis of neonatal hypoxic-ischemic encephalopathy. Methods: Thirty-seven newborns with hypoxic-ischemic encephalopathy admitted to our hospital were selected as research group and 40 healthy newborn infants were selected as control group. Both groups were examined by diffusion-weighted imaging and 1H magnetic resonance spectroscopy Group neonatal general MRI and diffusion weighted imaging examination results, comparing the relative concentrations of brain metabolic compounds in the study group and the control group. Results: Compared with the detection rate of ordinary MRI, the diffusive weighted imaging signals of the study group were significantly increased, the difference was statistically significant (P <0.05). The ratio of NAA / Cr in the study group was lower than that in the control group. The ratios of Cho / Cr, MI / Cr, Glu-Gln / Cr and Lac / Cr were higher in the study group than those in the control group (P <0.05). Conclusion: The combination of DWI and 1H magnetic resonance spectroscopy can improve the diagnostic accuracy when diagnosing neonatal hypoxic-ischemic encephalopathy. By analyzing the metabolite concentration, it is helpful to evaluate the damage of brain tissue caused by hypoxia-ischemia The severity of