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本研究应用抗ＰＣＮＡ（增殖细胞核抗原）单克隆抗体（ＰＣ１０）、采用Ｓ—Ｐ免疫组化法检测了４３例非小细胞肺癌中ＰＣＮＡ的表达。结果表明，３５例为阳性反应，阳性率为８１．３９％。随着癌细胞分化程度的降低，阳性细胞数增高，高分化肺癌为ＮＮ．０％±２４．９，中分为６５．９％±１１．７，低分化为７７．８±２０．２，各组间差异显著，提示ＰＣＮＡ表达可反应肺癌细胞的增殖活性，为研究肺癌的生物学行为提供了一个有用的标志物。
In this study, anti-PCNA (proliferating cell nuclear antigen) monoclonal antibody (PC10) was used to detect the expression of PCNA in 43 cases of non-small cell lung cancer by S-P immunohistochemistry. The results showed that 35 cases were positive and the positive rate was 81.39%. As the degree of differentiation of the cancer cells decreased, the number of positive cells increased and the well-differentiated lung cancer was NN. 0%±24.9, the median score was 65.9%±11.7, and the poor differentiation was 77.8±20.2. There was a significant difference among the groups, suggesting that the expression of PCNA may reflect the proliferative activity of lung cancer cells. The biological behavior provides a useful marker.