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目的调查社区中老年居民糖调节受损(IGR)各类型的分布情况,探讨该人群IGR发生的危险因素。方法对上海市杨浦区延吉社区2228例45～74岁居民进行空腹血糖检测,采用葡萄糖氧化酶-计量安培法进行测定。对筛检出的IGR人群进行问卷调查、体格检查、空腹血糖、糖负荷后2h血糖测定和血脂检测。结果共筛检出IGR者393例,其中,糖耐量正常者(NGT)占39.19%、空腹血糖受损(IFG)占12.72%、糖耐量受损(IGT)占16.54%、空腹血糖受损合并糖耐量受损(IFG+IGT)占16.03%、新发糖尿病(DM)占15.52%。不同年龄组,NGT、IFG、IGT、IFG+IGT和DM的构成比不同(χ2=21.295,P=0.006),IGT、IFG+IGT和DM的比例有随年龄增长而增加的趋势。不同体质指数人群中,NGT、IFG、IGT、IFG+IGT和DM的构成比不同(χ2=26.155,P=0.01),随体质指数的增加,糖代谢异常的比例逐渐增加。Logistic回归分析显示,该社区IGR的主要危险因素是糖尿病家族史(OR=1.945)、高血压病史(OR=1.884)、高三酰甘油(OR=1.469)、年龄(OR=1.038)。结论延吉社区中老年IGR人群以IFG+IGT、IGT为主,发生率随着年龄的增加而升高;IGR发生的危险因素为糖尿病家族史、高血压病史、高三酰甘油和年龄。
Objective To investigate the distribution of various types of impaired glucose regulation (IGR) in community residents and to explore the risk factors of IGR in this population. Methods Fasting blood glucose (FBG) was detected in 2228 residents aged 45 ~ 74 years in Yanji Community, Yangpu District, Shanghai. The glucose oxidase - metered amperometry was used to measure the fasting blood glucose. A questionnaire survey, physical examination, fasting blood glucose, blood glucose 2h after glucose load test and blood lipid test were performed on the IGR population detected. Results A total of 393 IGRs were screened out, of whom 39.19% had normal glucose tolerance (NGT), 12.72% had impaired fasting glucose (IFG) and 16.54% impaired glucose tolerance (IGT) Impaired glucose tolerance (IFG + IGT) accounted for 16.03%, new diabetes (DM) accounted for 15.52%. The proportions of NGT, IFG, IGT, IFG + IGT and DM were different in different age groups (χ2 = 21.295, P = 0.006). The proportion of IGT, IFG + IGT and DM tended to increase with age. The constitutional ratios of NGT, IFG, IGT, IFG + IGT and DM were different in different body mass index groups (χ2 = 26.155, P = 0.01). With the increase of body mass index, the proportion of abnormal glucose metabolism increased gradually. Logistic regression analysis showed that the main risk factors of IGR in this community were family history of diabetes (OR = 1.945), history of hypertension (OR = 1.884), high triglyceride (OR = 1.469) and age (OR = 1.038). Conclusion The prevalence of IGR in middle-aged and elderly patients in Yanji community is mainly related to IFG + IGT and IGT. The incidence of IGR increased with increasing age. The risk factors of IGR were family history of diabetes, history of hypertension, hypertriglyceride and age.