目的探索视网膜母细胞瘤综合治疗的疗效。方法视网膜母细胞瘤患儿37例(48只眼)采用手术、局部治疗和化疗相结合的综合治疗。结果随访6-48个月。IRC分期A-C期28只眼,应用化疗结合局部治疗,25只眼(89.3%)持续缓解,其余3只眼(10.7%)经化疗病情仍进展。IRC分期D-E期20只眼,应用眼球摘除术结合化疗,18只患眼(90.0%)随访均未发现新发病灶,1例双眼病例摘除眼球并化疗3次后出现病情进展。所有病例都能耐受化疗。结论综合治疗可以提高视网膜母细胞瘤患儿的保眼率及生存质量,并有希望保存患儿的有用视力。 Objective To explore the curative effect of comprehensive treatment of retinoblastoma. Methods 37 cases of retinoblastoma children (48 eyes) with surgery, local treatment and chemotherapy combination of comprehensive treatment. The results were followed up for 6-48 months. In the IRC stage, 28 eyes (A-C stage) were treated with chemotherapy combined with topical treatment, and 25 eyes (89.3%) sustained remission while the remaining 3 eyes (10.7%) were still undergoing chemotherapy. Twenty eyes of IRC stage D-E were treated with enucleation combined with chemotherapy, and 18 eyes (90.0%) were followed up. No new lesions were found in one eye of the IRC. All cases are resistant to chemotherapy. Conclusion Comprehensive treatment can improve the eye-holding rate and quality of life in children with retinoblastoma, and hopefully save the children with useful vision.