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目前科学家正在研究癌基因如何起始和维持细胞的肿瘤转化。发现这过程与正常细胞的生长控制有密切关系。一、生长因子对细胞的促分裂作用通常动物细胞的生长分裂限制于胚胎发育、新老更替和创伤愈合组织内。在体外培养中正常二倍体细胞的增殖需要多种生长因子(GF)的刺激,否则细胞只能处于休止状态,在整体内应亦如此。生长因子是细胞旁分泌(pa-racrine)的多肽分子,不进入管腔或血流,只扩散到附近局部区域内,对有表面受体(GFR)的细胞起作用。由于这些发现,Cohen和Levi
Scientists are currently studying how oncogenes initiate and maintain tumor cell transformation. This process was found to be closely related to the growth control of normal cells. First, the growth factor cytokinesis cell division usually animal growth and development limited to embryonic development, the old replacement and wound healing tissue. Proliferation of normal diploid cells in vitro requires stimulation of multiple growth factors (GFs), otherwise the cells can only be in a quiescent state, as well as within the whole body. Growth factors are pa-racrine polypeptide molecules that do not enter the lumen or bloodstream and only diffuse into nearby local areas and act on cells that have surface receptors (GFRs). Due to these discoveries, Cohen and Levi