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目的测定纤维结肠镜检查术患者靶控输注异丙酚的半数有效血浆靶浓度(EC50)。方法拟行纤维结肠镜检查术患者60例,ASA Ⅰ或Ⅱ级,按序贯法进行试验:初始血浆靶浓度设为5．0 μg/ml,入选样本从有体动的上1个患者开始计算,其后各例患者血浆靶浓度根据检查过程中有无体动进行调整,浓度变化间隔为0．5μg/ml。计算异丙酚的EC50及其95％可信区间。结果纤维结肠镜检查术患者靶控输注异丙酚的EC50为4．9μg/ml,95％可信区间4．5-5．4μg/ml。结论纤维结肠镜检查术患者靶控输注异丙酚的EC50为4．9μg/ml。
Objective To determine the half effective plasma target concentration (EC50) of targeted controlled infusion of propofol in patients undergoing colonoscopy. Methods Sixty patients with ASA Ⅰ or Ⅱ were enrolled in the study. The initial plasma target concentration was set at 5.0 μg / ml. The selected samples were taken from the upper one with physical activity Calculations, and each patient’s plasma target concentration in the course of the examination according to whether the body movement adjustment, the concentration change interval of 0.5μg / ml. Propofol EC50 and its 95% confidence interval were calculated. Results The target-controlled infusions of propofol in patients with colonoscopy were 4.9μg / ml and 95% confidence interval 4.5-5.4μg / ml. Conclusion The target-controlled infusion of propofol in patients with fibro-colonoscopy has an EC50 of 4.9 μg / ml.