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目的:探讨天脉消渴片联合胰岛素治疗2型糖尿病患者的临床疗效。方法:纳入符合条件的2型糖尿病患者60例,随机分为2组:试验组30例,皮下注射胰岛素同时口服天脉消渴片240mg/次,每天2次;对照组30例,单独胰岛素治疗。治疗12周后以糖化血红蛋白(HbA1c)、空腹血糖(FPG)及餐后2小时血糖(PG2h)等评价服用天脉消渴片的有效性。结果:入组60例患者,治疗24周后,2组HbA1c,FPG和PG2h较前均显著降低,2组比较差异有统计学意义(P<0.05)治疗组疗效优于对照组。2组治疗后HbA1c、FPG、PG2h组间比较差异均有统计学意义(P<0.05),治疗组改善优于对照组。结论:天脉消渴片联合胰岛素治疗2型糖尿病具有明显改善临床症状及协同降糖作用,在降糖效果及起效时间上也优于单独应用胰岛素同时低血糖发生率明显低于对照组。
Objective: To investigate the clinical efficacy of Tianma Xiaoke Tablet combined with insulin in the treatment of type 2 diabetic patients. Methods: A total of 60 eligible type 2 diabetic patients were enrolled in this study. They were randomly divided into two groups: 30 in the experimental group and 240 mg in subcutaneous injection of Tianma Diabetes tablets subcutaneously twice a day. In the control group, 30 patients received insulin alone . After 12 weeks of treatment, the effectiveness of taking Tianma Xiaoke Tablet was evaluated by HbA1c, fasting blood glucose (FPG) and postprandial 2-hour blood glucose (PG2h). Results: After treatment for 24 weeks, the HbA1c, FPG and PG2h in two groups were significantly lower than those in the previous two groups. The difference between the two groups was statistically significant (P <0.05). The curative effect of the treatment group was better than that of the control group. The difference of HbA1c, FPG and PG2h between the two groups after treatment was statistically significant (P <0.05), and the treatment group improved better than the control group. Conclusion: Tianma Xiaoke Tablet combined with insulin treatment of type 2 diabetes can significantly improve the clinical symptoms and synergistic hypoglycemic effect, in the hypoglycemic effect and onset time is also better than the single use of insulin at the same time the incidence of hypoglycemia was significantly lower than the control group.