细胞只有与基质粘着后才能进行扩展与迁移 ,位于细胞膜上通过整合素将胞外的基质分子与细胞内的骨架蛋白连接起来形成的大分子物质称为焦点粘附物。它在细胞的迁移过程中起重要作用 ,而细胞的迁移对于胚胎发育、炎症发生、伤口愈合、肿瘤形成与转移等事件的发生是必须的。另外 ,焦点粘附物在静止的成纤维细胞中以一定的速度向细胞中心线性运动 ,其运动的变化反映出细胞周期、细胞代谢活性及局部基质的不同 Cells only adhere to the substrate to expand and migrate, located in the cell membrane by integrin extracellular matrix molecules and intracellular matrix protein connected to form a macromolecular substance known as the focal adhesion. It plays an important role in the migration of cells, and the migration of cells is necessary for the occurrence of embryo development, inflammation, wound healing, tumor formation and metastasis. In addition, focal adhesion moves linearly toward the center of the cell at a constant rate in resting fibroblasts, and changes in motility reflect changes in cell cycle, cellular metabolic activity, and local stroma