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目的探讨抗环瓜氨酸多肽(CCP)抗体检测对类风湿关节炎(RA)早期诊断的意义。方法应用ELISA法检测2004—2005年中国医科大学附属盛京医院150份人血清的抗CCP抗体,包括54例RA患者,80例其它风湿病患者,16名正常人;并分析抗CCP抗体与类风湿因子(RF)、C反应蛋白(CRP)、血沉(ESR)的相关性。结果抗CCP抗体对RA的敏感性和特异性分别为70·4%和93·8%。发病2年内与2年以上的抗CCP抗体阳性率差异无显著性。抗CCP抗体阴性组与阳性组的关节畸形率差异无显著性。抗CCP抗体与RF、CRP、ESR无相关性。结论抗CCP抗体对RA具有较好的敏感性和很高的特异性,联合抗CCP抗体和RF可以提高诊断的准确性,对RA的早期诊断具有重要意义。
Objective To investigate the significance of detecting anti-cyclic citrullinated peptide (CCP) antibody in the early diagnosis of rheumatoid arthritis (RA). Methods The anti-CCP antibodies of 150 human serum samples from Shengjing Hospital affiliated to China Medical University from 2004 to 2005 were collected, including 54 patients with RA, 80 patients with other rheumatic diseases and 16 normal controls. The anti-CCP antibody and anti-CCP antibody Rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR). Results The sensitivity and specificity of anti-CCP antibody to RA were 70.4% and 93.8% respectively. There was no significant difference in the positive rate of anti-CCP antibody between 2 years and 2 years after onset. There was no significant difference in the rate of joint deformity between anti-CCP antibody negative group and positive group. Anti-CCP antibody and RF, CRP, ESR no correlation. Conclusion Anti-CCP antibody has good sensitivity and high specificity for RA. Combining anti-CCP antibody and RF can improve the accuracy of diagnosis, which is of great significance for the early diagnosis of RA.