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目的观察EPOCH方案治疗侵袭性非霍奇金淋巴瘤(NHL)的疗效和副作用。方法 31例非霍奇金淋巴瘤患者采用EPOCH方案治疗。EPOCH方案:依托泊苷(VP-16)50mg/m2,表柔比星(E-ADM)12mg/m2,长春新碱(VCR)0.4 mg/m2,溶解于生理盐水500ml中,持续静滴24h,第1～4天;环磷酰胺(CTX)750mg/m2静脉推注,第5天;强地松60mg/m2,口服,第1～5天,21天为1个周期,共进行4～6个周期。结果 31例患者总有效率为90.3%,完全缓解(CR)率为64.5%,部分缓解(PR)率为25.8%,主要不良反应为骨髓抑制、脱发、黏膜炎。结论 EPOCH方案是NHL经济、有效的治疗方案,毒性可耐受,值得在临床上推广应用。
Objective To observe the efficacy and side effects of EPOCH regimen in the treatment of aggressive non-Hodgkin’s lymphoma (NHL). Methods 31 patients with non-Hodgkin’s lymphoma were treated with EPOCH regimen. EPOCH regimen: Etoposide (VP-16) 50mg / m2, epirubicin (E-ADM) 12mg / m2, vincristine (VCR) 0.4mg / m2, dissolved in 500ml of saline for 24h , 1 to 4 days; cyclophosphamide (CTX) 750mg / m2 intravenous injection, the first 5 days; prednisone 60mg / m2, oral, 1st to 5th days, 21 days for a cycle, a total of 4 ~ 6 cycles. Results The total effective rate of 31 patients was 90.3%. The complete remission (CR) rate was 64.5% and the partial remission (PR) rate was 25.8%. The main adverse reactions were myelosuppression, alopecia and mucositis. Conclusion The EPOCH regimen is an economical and effective treatment regimen for NHL. Its toxicity is tolerable and worth popularizing in clinic.