论文部分内容阅读
目的 研究塔里木盆地子午沙鼠 (Merionesmeridianus)对从新疆和田喜马拉雅旱獭鼠疫疫源地分离的 470 0 4号鼠疫菌、乌恰县灰旱獭体分离的 2 110 6号菌株和内蒙古长爪沙鼠体分离的 980 0 5号鼠疫菌株感染子午沙鼠在病理改变、感受性、敏感性、二次感染后抗性等方面有无差异 ,仔鼠体内的母系抗体维持时间。方法 用分离自喜马拉雅旱獭体的鼠疫菌 470 0 4号 ,以 1× 10 1 ～ 1× 10 1 0 个菌皮下接种从塔里木盆地捕获的子午沙鼠。结果 本次试验株与 980 0 5株不同剂量感染后死亡情况大致相同 ,二者与 2 110 6株感染结果有较大差异。二次接种 1× 10 1 0 个鼠疫菌 ,存活鼠在饲养 5个月、10个月后产仔 ,从父本、母本、仔鼠体内均测出鼠疫F1抗体。结论 2 110 6株对子午沙鼠的LD50 与 980 0 5株和本次试验株LD50 有较大差异 ,前者毒力较强。再次证实子午沙鼠♀鼠抗体可通过胎盘传递 ,且仔鼠至少能维持抗体 2个月
Objective To study the isolation of 470 0 4 Yersinia pestis from Meriones meridianus in the hinterland of Himalayan tribes from Wada in the Tarim Basin, 2 1106 strains isolated from the marmot 980 0 5 plague strains inoculated with Meriones unguiculatus in pathological changes, sensitivity, sensitivity, resistance after secondary infection and so there is no difference in offspring maternal antibody maintenance time. Method Meriones unguiculatus captured from the Tarim Basin was subcutaneously inoculated with 1 × 10 1 to 1 × 10 10 strains of Y. pestis 470-4 from the Himalayan marmot. Results The death rate of the test strain and 980 0 5 strains at different doses was approximately the same, and the difference between the two strains and 2 110 6 strains was quite different. The second vaccination of 1 × 10 10 Yersinia pestis, the survival of rats in feeding 5 months, 10 months after litter, from the male parent, female offspring were measured in vivo F1 antibody. Conclusion 2 110 6 strains of Meriones unguiculatus LD50 and 980 0 5 strains and this test strain LD50 are quite different, the former virulence is strong. Once again confirmed that the gerbils zingiber zingiberis antibodies can be transmitted through the placenta, and pups can maintain antibodies at least 2 months