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粪便隐血试验已广泛应用于直肠癌的筛检,但其能否降低癌死亡率目前尚无确切的证据。本文报道一随机检测粪便隐血筛检大肠癌的结果。 方法:46,551名50至80岁受检者随机分为筛检组和对照组,其中筛检组又分为每年一次和两年一次普查组。筛检组中每一受试者作愈创木脂试剂纸片(Hemoccult试纸)的粪便涂片检查,连续三次大便每次涂片2张。对试验阳性者作包括结肠镜在内的进一步检查。每一筛检组与对照组间大肠癌死亡率的差异
Fecal occult blood tests have been widely used for the screening of rectal cancer, but there is no clear evidence of its ability to reduce cancer mortality. This article reports a random test of fecal occult blood screening for colorectal cancer. Methods: A total of 46,551 50 to 80-year-old subjects were randomly divided into a screening group and a control group. The screening group was divided into once-a-year and bi-annual screening groups. Each subject in the screening group was tested for fecal smears of Hectospirit Reagent Sheets (Hemoccult test strips), and two stools were smeared twice each time for three consecutive sessions. For those who tested positive for further examination including colonoscopy. Differences in colorectal cancer mortality between each screening group and control group