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【目的】探讨应用神经内镜辅助钬激光疗法与立体定向放射疗法治疗颅内肿瘤的临床效果。【方法】从本院2010年1月至2013年1月收治的颅内肿瘤患者中选取80例为观察对象，按患者治疗意愿分为观察组与对照组，每组40例。对照组行立体定向放射治疗，观察组行神经内镜辅助钬激光治疗；观察比较两组患者治疗效果，并发症发生情况，远期生存情况及生活质量。【结果】观察组治疗总有效率为92．50％（37／40），明显高于对照组72．50％（29／40），且差异具有显著性（ P＜0．05），观察组并发症发生率为10．00％（4／40），明显低于对照组27．50％（12／40），且两组相比较差异具有显著性（ P ＜0．05）。观察组6个月、12个月生存率分别为95．00％（38／40）、77．50％（31／40），明显高于对照组85．00％（34／40），62．50％（25／40），且两组相比较差异具有显著性（ P ＜0．05），观察组生活质量显著优于对照组，且两组相比较差异具有显著性（ P ＜0．05）。【结论】在颅内肿瘤治疗中，选择神经内镜辅助钬激光疗法，疗效确切，安全性高，能有效改善预后，提高患者生存率及生活质量，值得临床推广应用。“,”[Objective] To explore the clinical efficacies of neuroendoscope assisted holmium laser treatment and stereotactic radiosurgery for intracranial tumors .[Methods] From January 2010 to January 2013 ,a total of 80 patients with intracranial tumors were randomly divided into observation and control groups ( n =40 each) .The control group had stereotactic radiotherapy while the observation group received neuroendoscope plus holmium la‐ser treatment .And their efficacies ,complications ,long‐term survival and life quality were compared .[Results]The overall efficacy rate of observation group was [92 .50% (37/40) vs 72 .50% (29/40)] .And the difference was statistically significant ( P <0 .05) .The incidence of complications was 11 .90% in observation group versus 23 .81% in control group .And the difference had statistic significance ( P<0 .05) .The survival rates of 6 and 12 months were obviously higher in observation group (95 .2% ,78 .57% ) than control group (85 .71% ,64 .29% ) . And the differences had statistic significance( P <0 .05) .Life quality was obviously better in observation group than that in control group .And there was statistic significance( P<0 .05) .[Conclusion]Neuroendoscope assisted holmium laser treatment is both curative and safe for intracranial tumors .And it can improve prognosis ,survival rate and life quality .Wider application is recommended .