本病成人少见,系慢性良性疾病,发生于粘膜和皮肤,偶伴隐性糖尿病。本文报告一例男性,61岁,患隐性糖尿病,以氯磺丙脲内服控制症状。6个月后腋部出现黄色丘疹,继之发展至颏、唇、眶周及颈前部,硬腭、软腭、上牙槽也有黄色斑块。右臂活检证实为黄瘤。各种化验及X线检查均正常。因此病与Hand-SchullerChristian氏病相似且后者治以长春新硷有效(Starlings等,1972),故亦用长春新硷治之,但无进步。又一例男性,15岁,患流感,6周后乏力厌食,体重减轻30磅,又一个月后,面背部出现无痒棕色丘疹并向胸与四肢发展,以激素及维生素B_(12)治疗无效。活检为散发性黄瘤。随访二年,黄瘤浸润消失,变为色素沉着的萎缩疤痕。 This disease is rare in adults, is a chronic benign disease, occurs in the mucous membranes and skin, even with hidden diabetes. This article reports a case of a male, 61 years old, who suffered from occult diabetes and was controlled by oral administration of diclofenac. Six months later, yellow pimples developed in the ankles, followed by ankles, lips, ankles, and anterior cervical spine. There were also yellow plaques in the hard palate, soft palate, and upper alveolar ridge. The right arm biopsy was confirmed as a xanthoma. All kinds of tests and X-ray examinations are normal. Therefore, the disease is similar to Hand-Schuller Christian's disease and the latter is treated with Changchun Xinjing (Starlings et al., 1972), so it is also treated with Changchun Xinzhi, but no progress has been made. Another male, aged 15 years, suffering from influenza, anorectic after 6 weeks, weight loss 30 pounds, after another month, no itch brown pimples on the back of the face and development of the chest and limbs, treatment with hormones and vitamin B_(12) . The biopsy was sporadic xanthoma. After two years of follow-up, infiltration of the xanthoma disappeared and it became a hyperpigmented scar.